Efficacy and safety of fentanyl buccal for cancer pain management by administration through a soluble film: an update
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چکیده
منابع مشابه
Efficacy and safety of fentanyl buccal for cancer pain management by administration through a soluble film: an update
More than half of patients receiving prescription medicine for cancer pain have been reported to experience inadequate pain relief or breakthrough pain. Buccal administration can deliver lipophilic opioids rapidly to the systemic circulation through the buccal mucosa, limiting gastrointestinal motility and first-pass metabolism. This review updates the safety and efficacy of fentanyl buccal sol...
متن کاملSafety and effectiveness of fentanyl administration for prehospital pain management.
OBJECTIVE To determine the safety and effectiveness of fentanyl administration for prehospital pain management. METHODS This was a retrospective chart review of patients transported by ambulance during 2002-2003 who were administered fentanyl citrate in an out-of-hospital setting. Pre- and post-pain-management data were abstracted, including vital signs, verbal numeric pain scale scores, medi...
متن کاملSingle-Dose Pharmacokinetics of Fentanyl Buccal Soluble Film
OBJECTIVE The objectives of the study were to determine the absolute bioavailability of fentanyl from fentanyl buccal soluble film, estimate the percentage of a fentanyl dose absorbed through the buccal mucosa, and compare the bioavailability of equivalent doses administered either as single or multiple dose units. DESIGN Open-label, randomized, four-period, Latin-square crossover pharmacokin...
متن کاملFentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study
BACKGROUND Fentanyl buccal soluble film (FBSF) has been developed as a treatment of breakthrough pain in opioid-tolerant patients with cancer. The objective of this study was to evaluate the efficacy of FBSF at doses of 200-1200 microg in the management of breakthrough pain in patients with cancer receiving ongoing opioid therapy. PATIENTS AND METHODS This was a multicenter, randomized, doubl...
متن کاملAn Investigation of Safety and Efficacy of Intravenous Paracetamol in Pain Management Following Cardiac Surgery
Introduction: Optimum pain management immediately after surgeries can lower the possibility of pain syndrome and its following consequences. Opioids are amongst the analgesics used for postoperative pain control; however, their application can bring about several adverse effects. In this study, all the published articles regarding efficacy of Paracetamol in post-cardiac surgery pain managemen...
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ژورنال
عنوان ژورنال: Cancer Management and Research
سال: 2010
ISSN: 1179-1322
DOI: 10.2147/cmr.s7215